Insect pest management by cultural control practices

The insect pest management can be done from various general perspectives. It’s beneficial to take into account every possibility when creating a comprehensive pest management plan.

Cultural control practices

Cultural controls entail changing conventional agricultural methods to keep pests away or create an environment that is less conducive to their presence. There are many different kinds of cultural controls; some popular ones are listed here. Through crop rotation, a crop that is seriously pest-prone is periodically replaced with a crop that is not. For instance, you can starve corn rootworm larvae by planting non-host crops like soybeans, alfalfa, or oats for one to two years after corn. Keeping the space free of any debris or plants that could attract pests is referred to as sanitation. Examples include clearing out weeds that could harbor mites, aphids, or whiteflies from greenhouses; destroying crop residues like corn stubble, squash vines, or fallen apples that could serve as pest overwintering grounds; cleaning farm equipment that could harbor pests and transfer them from one field to another; and managing and removing manure that could serve as a breeding ground for flies.

Poly-culture refers to the practice of planting multiple crops near together. This technique not only creates a challenging environment for pests to identify their preferred host crop, but it also fosters a favorable environment for beneficial natural enemies.

Read: Principal classes of conventional insecticides used to manage insect pests

Strip cropping, which involves planting a variety of field crops in parallel strips, including alfalfa, soybeans, corn, and minor grains, again contributes to the habitat diversity that is beneficial to natural control. By placing a pest insect’s favorite food close to the crop that needs to be safeguarded, a practice known as trap cropping is used to draw the insects to the crop, which is eventually destroyed. For instance, pickleworms will congregate in squash plants placed close to cucumbers, potentially destroying the squash plants. A thoughtful planting schedule might help prevent certain pest issues, including seed corn maggot. This preventive measure is cheap and could be more effective if used after gaining a thorough understanding of the life cycle and habits of a pest. Some of the key steps included in this control method are deep plowing after crop harvesting (to reveal insects hiding and resting), removing and destroying appropriate and other trash, adjusting sowing time (to avoid the peak incidence period), clean cultivation, the removal of alternative wild hosts, catch crops, and suitable rotations.

Controlling pests can often be as easy as making a few surprising but effective changes to their habitat or surroundings. Generally speaking, because they often entail modifications to conventional horticultural, silvicultural, or animal husbandry techniques, these strategies are referred to as cultural control approaches. They are also known, less frequently, as ecological control methods since these strategies typically alter the interactions between a pest population and its natural environment. The main benefits of cultural control strategies are their simplicity and low cost; drawbacks are minimal if these strategies align with a farmer’s other management goals (high yields, mechanization, etc.).

Unfortunately, cultural approaches alone cannot effectively reduce the vast majority of insect pests. Among the earliest and most successful methods of cultural management is crop rotation. In the same field, growing the same crop year after year allows insect populations enough time to establish themselves and grow to harmful levels. By starving pests that are unable to adapt to a new host plant, this cycle can be broken by rotating the field to a different crop. By substituting oats, wheat, or legumes for corn, farmers in the Midwest, for instance, can lower the numbers of wireworms (Elateridae) and rootworms (Diabrotica spp.) in corn fields. Similarly, moving from clover or alfalfa to maize or small grains will eradicate the clover root curculio, which feeds only on legumes. In pasture areas, rotation programs have been shown to be effective in managing pests.

Crop rotation programs are effective because they diversify a pest’s surroundings and interrupt its feeding source. Rotations typically work best and most practically for insect pest management when they are applied to pests that:

  • attack annual or biennial crops
  • have a relatively narrow host range
  • cannot move easily from one field to another, and
  • are present before the crop is planted

Read: Insect pest management with insecticides and development of resistance

Increasing environmental diversity by intercropping, often called mixed cropping, is another strategy to lower insect populations. When host and non-host plants are combined in a single planting, for example, intercropping can sometimes make the environment less visually pleasing overall. In other situations, however, intercropping might concentrate the pest in a more manageable, smaller area, making it easier to control with another strategy. For instance, cotton and alfalfa strips are occasionally planted together as a lygus insect (Miridae) trap crop. Since alfalfa is a stronger attractor of lygus bugs than cotton, it is typically treated with a pesticide to eradicate the bugs before they spread to cotton fields nearby.

Just changing when to sow or harvest certain crops can cause a disruption in the pest’s food source. Farmers can manage their crop to stay “out of phase” with insect populations by using this tactic, sometimes referred to as phenological asynchrony. For example, if sweet corn is planted early in the spring and harvested before the larvae grow, it can withstand the majority of the damage caused by corn earworms (Helicoverpa zea). Midwest farmers wait to grow winter wheat until after the “fly-free date” in order to shield their crop from damage caused by the Mayetiola destructor, or Hessian fly.

Read: Insect pest management by chemical control of behavior, reproduction, and development

The most practical strategy accessible to foresters for managing bark beetle (Scolytidae) infestations in pine plantations is frequently harvest timing. Good management requires that timber stands be cut for lumber before the trees reach full maturity, as older trees are more vulnerable to beetle outbreaks.

The idea behind the term “pest management” is to regulate populations of pests rather than eradicate them. The methodical control of pest populations below the point of economic or aesthetic harm is known as pest management. It requires some understanding of the life cycles of insects as well as how the physical environment affects the survival, reproduction, and dispersal of pests for insect pest management.

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Principal classes of conventional insecticides used to manage insect pests

Currently, over 400 distinct chemical compounds are approved for use as insecticides. They reflect a broad spectrum of physical characteristics, toxicity, and chemical structures. Certain insecticides are used for a wide range of purposes, whereas others are highly specialized and have restricted use. Furthermore, a great deal of other substances that were once in use are no longer accessible due to their high toxicity, protracted persistence, or lack of trustworthiness. Some of the more significant pesticides from the past and present are included in the list below, which is arranged according to chemical families.

Inorganic compounds

Throughout most of the 1800s and 1900s, the cornerstones of chemical pest management were chemicals containing arsenic and fluoride. Lead arsenate, arsenic trioxide, and copper acetoarsenate (Paris green), for example, are substances that are very hazardous to all animals and persistent in the environment. Following World War II, the majority of inorganic compounds were phased out of use. They were swapped out by less dangerous and more effective synthetic organic chemicals. Despite their widespread use, stomach poisons such as sodium fluoride (NaF) and sodium fluoroaluminate (Na3AlF6) are still used in cryogenic applications. Sulfur that has been finely pulverized is also utilized as a miticide and fungicide.

Oil and soaps

Crop oils, also referred to as dormant oils, are water emulsions made from petroleum distillates. By covering and smothering tiny insects or their eggs, they work. Vegetable or animal oils are the basis for insecticidal soaps. As contact insecticides, they have been in use since 1787. The best insecticides for scale, aphids, whiteflies, and phytophagous mites are oils and soaps.

Read: Insect pest management with insecticides and development of resistance

Botanical extract

Plant extracts have been used to kill insects since ancient times. These compounds represent a wide range of chemical structures and activities.

Nicotine

  • Source: Nicotiana spp. (tobacco) — Solanaceae. Commercially available in the forms of nicotine fumigant or nicotine sulfate dust.
  • Activity: Mimics the actions of acetylcholine in the synapses between nerves, resulting in tremors, loss of coordination, and ultimately death.

Rotenone

  • Source: Leguminaceae, a family of tropical legumes. Lonchocarpus species grown in South America and Derris species growing in Malaysia and the East Indies
  • Activity: The metabolic toxin rotenone. It does this by preventing NADH2dehydrogenase, an important enzyme, from doing its job, which delays electron transport during aerobic respiration. Fish are very poisonous to rotenone.

Pyrethrum

  • Source: Asteraceae (Chrysanthemum spp.). Two species that are farmed commercially in Kenya account for the majority of the world’s supply.
  • Action: Pyrethrums alter the nerve axon’s sodium channels’ permeability. Usually, this causes excitement, incoordination, and paralysis. Since the effects of pyrethrum poisoning are typically reversible, commercial pesticides usually contain a synergist, such as piperonyl butoxide, that prevents the insect’s detoxication route.

Organochlorines

The earliest synthetic organic pesticides that were ever found were these. DDT and its derivatives (such as methoxychlor and kelthane), lindane, toxaphene, and insecticides containing cyclodiene (such as aldrin, dieldrin, endrin, mirex, chlordane, heptachlor, and endosulfan) are included in this group. As nerve poisons, the majority of organochlorines, sometimes referred to as chlorinated hydrocarbons, are rather stable substances. In fat (lipid) as opposed to water, they are thousands of times more soluble. Accordingly, they have a propensity to concentrate in species at the top of a community’s food chain and accumulate in fatty tissues (a process known as bioaccumulation). Because of the long-term persistence and bioaccumulation of organochlorines, most of their usage have been outlawed or ceased in the United States due to environmental concerns.

Read: Insect pest management by chemical control of behavior, reproduction, and development

Organophosphates

First identified as a byproduct of nerve gas research, these chemicals were discovered by German scientists in the late 1930s. They do not accumulate in adipose tissues and are far less persistent than the organochlorines. These include a variety of all-purpose insecticides with varying degrees of toxicity to mammals (such as malathion, parathion, diazinon, chlorpyrifos, azinphosmethyl, acephate, phorate, and phosmet), as well as substances that function as fumigants (DDVP, for example) and systemics (dimethoate, disulfoton, demeton, and ronnel). Nerve toxins are present in all organophosphates. The neurotransmitter substance acetylcholine is broken down and removed from the neuron synapses by an enzyme called acetylcholinesterase, which is blocked in this way. Acetylcholine overstretching causes hyperkinetic symptoms such as seizures, tremors, and finally death.

Carbamates

This broad class of insecticides, which was first created in the early 1950s, is similar to the organophosphates in many ways, including having a similar mode of action, being biodegradable, having a poor solubility in fat, and having a broad spectrum of toxicity to mammals. Probably the most well-known and commonly used carbamate, carbamate (Sevin) is also the least harmful to people. Other carbamates are aldicarb, bendiocarb, formetanate, oxamyl, methomyl, propoxur, bendiofuran, and oxamyl (the last three are plant systemics). Carbamates have an advantage over organophosphates in that their inhibitory effect with acetylcholinesterase is reversible. Therefore, compared to chronic exposure to organophosphates, chronic exposure to carbamates is less likely to result in sickness.

Synthetic Pyrethroids

These pesticides, which are based on a natural substance present in chrysanthemums, are extremely harmful to insects yet generally safe for people to use. Because natural pyrethrum degrades quickly in the sun, it is almost useless outside. In 1967, the first light-stable counterpart, resmethrin, was created, and by 1976, fenvalerate and permethrin were offered for sale as pesticides for agriculture. These substances all function as nerve poisons, and they seem to work similarly to some of the organochlorines in disrupting sodium transport in axons.

Foramidines

In the 1970s, certain substances (such as amitraz and chlordimeform) were initially created for commercial usage. They most likely mirror the actions of the neurotransmitter octopamine, which is present in the central nervous system of the insect. They have been discovered to be effective in treating certain pests that have developed resistance to organophosphates or carbamates because of their unique method of action.

Organosulfurs and Organotins

These substances (such as tetradifon, cyhexatin, hexakis, and aramite) work far better against phytophagous mites than they do against insects. Consequently, they find widespread application as miticides in nurseries, orchards, and greenhouses. Because of their ovicidal action, or ability to destroy eggs, organosulfurs are particularly helpful.

Avermectins

The components of this novel class of compounds were extracted from Streptomyces avermitilis, a soil-dwelling fungus. These insecticides, which include ivermectin, abamectin, and avermectin, block the transmission of nerve impulses across the neuromuscular synapse, resulting in death and paralysis. The only organisms that the avermectins impact are insects, phytophagous mites, and specific plant-parasitic nematodes. This is a somewhat limited range of activity.

Nitroguanidines

The first insecticide in this new class of chemical pesticides is imidacloprid. It works against a broad range of sucking insects, including aphids, leafhoppers, and whiteflies, both systemically and by touch. The way imidacloprid works seems to be similar to how nicotine works at the neuronal synapse: it causes tremors, loss of coordination, and finally death by imitating acetylcholine’s activity.

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Insect pest management with insecticides and development of resistance

Insecticides are a crop protection tool used in agriculture to manage damage caused by harmful insects, either by exterminating them or limiting undesirable or harmful activities.

Over time, insect populations will continue to diversify and increase, severely harming crops and decreasing yields everywhere they go. Chewing, sucking, and piercing insects in the soil and on the plant endanger farmers’ livelihoods and destroy crops that are vital to feed a world population that is expanding quickly.

Insecticides are vital for managing insect pests, and enhancing the well-being of people, domesticated animals, and cattle.

Conventional Insecticides

Among the most often used chemical control agents are conventional pesticides due to their accessibility, quick action, and exceptional dependability. A single treatment may eradicate many pest species and typically leave behind a long-lasting residue that kills insects for hours or even days. Chemical control has been heavily criticized as a result of the overuse, abuse, and misuse of these substances, which have also occasionally had long-term negative effects on the environment.
When and where a bug comes into contact with a pesticide often determines its effectiveness. The exoskeleton of an insect absorbs the majority of pesticides immediately. The fact that these substances work “on contact” is why they are referred to as contact poisons. The tracheal system of the insect allows them to enter its body after being expelled as gases, or vapors. Utilizing fumigants in a confined space, like a grain bin, warehouse, or greenhouse, maximizes their effectiveness. To exert their effects, certain chemicals need to be consumed. Stomach poisons are the term for them. Although their efficacy is frequently lower than that of fumigants or contact poisons, they can nevertheless be beneficial for specific pest management applications in residential and commercial settings.

Read: Insect pest management by chemical control of behavior, reproduction, and development

Systemic insecticides

One particular kind of gastric toxin is systemic insecticides. The tissues of a plant (or animal) absorb these substances without experiencing any negative side effects. When insect pests feed on the treated organism, they absorb the pesticide. To protect domestic animals against internal parasites (such as cow grubs and various bot bugs), systemic insecticides are occasionally added to their food. You can add plant systems to the soil surrounding bedding plants or ornamentals. Insecticides are taken up by the roots and then moved to the leaves, stems, and flowers. The insect that feeds on the treated plant can be discouraged from eating if it does not get a deadly dosage of pesticide.

A toxicant, or poison, is one or more of the active chemicals found in insecticides. When these substances are at their most pure (technical grade), they could be too volatile, too unstable, or too poisonous to handle or use properly. Therefore, to enhance a commercial product’s efficacy, safety, or handling qualities, technical-grade insecticide is always combined with other substances, sometimes referred to as adjuvants. Formulations are these combinations of technical grade insecticide and adjuvants. Despite being identified as “inert ingredients” on the label, these substances are most definitely not inert. Numerous adjuvants are exclusive goods that are highly guarded as trade secrets and covered by patents. They might make up 90–95% of the volume of a product that is sold commercially.

There exist several formulations for insecticides that are customized for distinct uses. Several popular formulas consist of:
Grain or pellets (P) — Some forms of pesticides can be carried by coarse particles, such as walnut shells, powdered maize cobs, or clay. Through a delayed release process, the toxicant maximizes its active life (persistence) and reduces its mobility across the environment. In systemic insecticides (see above), which are sprayed around the base of plants, granular formulations are frequently employed to suppress soil-dwelling insects. When it comes to inadvertent human exposure, granular formulations are seen to be somewhat safe because they don’t blow or drift.

Read: Control of insect pests by means of chemical methods

Biochemical resistance

Changes in the metabolic pathways that insects typically exploit to degrade environmental toxins and plant defenses are usually involved in biochemical resistance. Enzymes such as hydrolases, oxidases, transferases, and esterases help detoxicants by altering their chemical structures before they cause harm to the body.

Physiological resistance

Physiological resistance involves alterations to basic life processes that have a functional impact on how toxicants interact with the body. For example, because of genetic alterations in the permeability of their cuticle, many cockroaches have developed resistance to the carbamate pesticide carbaryl.

Behavioral resistance

Any intrinsic behavioral alteration that lowers an insect’s likelihood of coming into contact with a toxicant may cause behavioral resistance. The malaria-carrying Anopheles mosquitoes in some regions have developed a hypersensitivity to specific pesticides. By avoiding confined spaces and avoiding landing on treated surfaces, they can evade deadly dosages of pesticides.

Insect populations that develop resistance to one pesticide may also exhibit reduced susceptibility to other toxicants belonging to the same chemical family. All four major families of insecticides (synthetic pyrethroids, carbamates, organochlorines, and organophosphates) share the issue of class resistance. Users usually switch out insecticides with another substance from a different chemical group when pest resistance renders them ineffective. However, developing resistance to one class of chemicals does not stop people from developing resistance to other chemical groups’ compounds later on.

Some bugs have become resistant to almost all of the insecticides that have ever been used to control them throughout time. Although controlling these substances can extend their useful life, it may never be feasible to stop insects from becoming resistant.

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Insect pest management by chemical control of behavior, reproduction, and development

Chemical controls are available for almost all insect pests. They are extensively employed in developed countries for several reasons, including their great effectiveness—one product frequently eradicates many pests—relatively cheap labor and product costs, and typically consistent and predictable results. Because chemical pesticides need less labor for mechanical and physical controls, fewer people may manage bigger acreages. Chemical pesticides have been crucial in the fight against disease-carrying insects like malaria mosquitoes and their usage in agriculture.

Chemical control of behavior

Semiochemicals are chemical compounds produced by plants and animals that cause behavioral or physiological reactions in members of the same or other species. An insect’s environment’s chemicals influence a large portion of its behavior. It is frequently feasible to use these substances to our benefit to repel pests from our houses, crops, or domestic animals, or to draw them to traps or baits. Numerous chemical substances can convey behavioral signals. These substances are referred to as semiochemicals together. Under some circumstances, they could help in communication (like pheromones) or between members of other species (like allelochemicals).

Read: Control of insect pests by means of chemical methods

Among the most potent chemical attractants are sex pheromones. These compounds have generated a lot of attention since A. A. Budenandt identified them in 1959 (from silkworm moths, Bombyx mori), due to their possible use as pesticides. Chemists have discovered the sex pheromones for more than 300 insect species in the last 30 years. These days, a lot of these compounds are offered for sale. Pheromones are sometimes encapsulated or bundled in slow-release dispensers (such as hollow fibers, rubber septa, or rope wicks) that are employed as lures in different kinds of traps. These pheromone traps are an effective monitoring tool at low concentrations, offering data on the density and dispersion of insect populations.

Additional helpful strategies for controlling insect behavior are chemical repellents and feeding deterrents. These substances, as their name implies, induce insects (or other arthropods) to disperse or cease their typical feeding habits. Artificial insect repellents, such as benzyl benzoate, dimethyl phthalate, and N, N-diethyl-m-toluamide (DEET), are designed to shield people from biting flies, ticks, and chiggers (immature trombiculid mites). Cattle are treated against flies with other substances such as butoxypolypropylene glycol or di-n-butyl succinate. To stop a variety of insects that feed on stored goods and natural fibers from invading drawers and closets, mothballs and flakes (also known as alpha-naphthalene or parachlorobenzene) are placed inside.

Chemical Control of Reproduction

It is known that more than 400 chemical compounds may render insects sterile during reproduction. While some of these substances seem to cause fundamental alterations in the chemical structure of nucleic acids, others hinder the growth and development of ovaries (DNA and RNA). These modifications, or mutations, impede normal embryonic development or stop cell division. These substances are either sprayed on the bug directly or mixed with food that is used as a lure.

Every chemical used in chemosterilants is quite dangerous. Not only do they affect insects, but they also cause cancer, birth abnormalities, and other alterations in both domestic animals and people. Needless to say, unlike other pesticides, these substances cannot be released into the atmosphere. Rather than being used on insects that are mass-reared and released as part of a sterile release program, they must be administered in a controlled laboratory setting. The discovery of a chemosterilant with insect-specific effects is highly desirable, but none has been discovered as of yet.

Chemical Control of Development

Chemical control weapons can occasionally be made from the enzymes and hormones found in an insect’s body that govern its developmental stages. Often referred to as insect growth regulators (IGRs), these substances can either hinder or accelerate development depending on the situation. IGR compounds fall into the following main groups:

Chitin inhibitors

These substances, such as diflubenzuron and diflubenzuron, prevent chitin synthetase from working, which is an enzyme required by epidermal cells to build a new exoskeleton, thereby inhibiting the molting process (apolysis). Chitin inhibitors are very specialized to arthropods due to their manner of action. They begin to act slowly—between two and five days—but eventually, they stop any activity that involves growing new cuticles, such as molting, hatching, or pupation. When applied to a pest during its juvenile phases, they work best. Currently licensed under the trade name Dimilin, diflubenzuron is used to manage a variety of pests, including boll weevils and gypsy moths.

Juvenile Hormone

Insect growth is regulated by juvenile hormone (JH) and its related substances, which prevent the developmental changes linked to morphogenesis, reproduction, and embryogenesis. JH levels in larvae (or nymphs) are increased throughout normal development and fall before pupation (or adult eclosion). When JH analogs are exposed in contact at the egg stage or during the last molt of the larval (or nymphal) stage, it can impede development, postpone maturation, and ultimately cause mortality. JH analogs are not very useful in agriculture since the onset of death is typically relatively gradual (days to weeks). However, several substances (such as methoprene, kinoprene, and hydroprene) have been effectively added to home goods to control fleas, ants, and other pests.

Anti-juvenile Hormones

First identified in 1976 from an ordinary houseplant (Aegeratum houstonianum), these special chemicals are known as precocious. Cell-killing substances are precocious. Enzymes in the insect’s corpora allata cause them to become active, killing out these glands specifically and stopping the manufacture of juvenile hormones in the future. The early (precocious) development of adult features or behaviors in juvenile insects can be caused by exposure to anti-JH chemicals. When the juvenile hormone is required for regular egg and sperm production, precocious can result in infertility in adults. When it comes to Hemipterans, anti-JH chemicals appear to work well. Because these IGRs degrade too quickly in the presence of oxygen, although having a unique method of action, they have never been developed into commercial goods.

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Control of insect pests by means of chemical methods

Chemical pesticides date back 4,500 years when the Sumerians used sulfur compounds as insecticides. Chemical pest management gained popularity when Paul Muller identified the insecticidal characteristics of DDT in 1939. The technique has gained so much traction that whenever the subject of pest management comes up, the majority of growers and extension agents exclusively discuss insecticides. Its remarkable and instantaneous outcomes are primarily responsible for its widespread use. This entails using chemicals to eradicate pests or prevent them from reproducing, feeding, or engaging in other necessary activities. Chemicals that are employed in chemical control might be entirely synthetic, natural goods, or synthetic materials that mimic natural items.

Generally non-toxic to insects, repellents, confusants, and irritants obstruct their natural behavior, preventing the insects from inflicting harm. Mothballs and insect repellents are well-known instances. The term “mating disruption” refers to the practice of employing synthetic sex pheromones on a large scale to the point that insects get so confused that they are unable to mate and have progeny. Pheromone flakes are being dropped from aeroplanes to treat huge areas of land in an effort by the WDNR to prevent the spread of gipsy moths in Wisconsin. Certain commercially available treatments are designed to manage other insects, including codling moths in apples.

Read: Insect management using mechanical control techniques

For almost every insect problem, chemical controls have been developed, especially synthetic organic pesticides. They are extensively employed in developed countries for several reasons, including their great effectiveness—one product frequently eradicates many pests—low labor and product costs, and typically consistent and predictable results. Because chemical pesticides need less labor for mechanical and physical controls, bigger acreages may be managed by fewer people. Chemical pesticides have been crucial in the fight against disease-carrying insects like malaria mosquitoes, in addition to their usage in agriculture.

However, chemical controls have several drawbacks. Firstly, most of them are highly toxic to beneficial insects like pollinators and predatory and parasitic natural enemies. Secondly, both target and non-target insects can develop resistance to insecticides, sometimes very quickly. Thirdly, because they have biological activity against many forms of life, they can affect non-target organisms. For the same reason, they present varying degrees of hazard to humans, especially pesticide applicators and other farm workers. Agriculture has been moving away from a more natural, balanced condition due to an over-reliance on pesticides and a decrease in the usage of alternative management measures.

A few commercially available synthetic sex pheromone compounds, such as those used to control codling moths in apples, may confuse insects to the point that they are unable to pair and generate progeny when used widely. Mating disruption, the term for this method of applying insect pheromones, is most effective in big commercial plantings because it reduces the likelihood that mated females will enter the planting from beyond the treated region. Many of these behavioral chemical kinds degrade or wash off easily, necessitating repeated reapplications, usage in confined spaces, or formulations intended for delayed release over an extended period.

Various commercially available toxins, some derived from natural sources and others synthesized, are classified as insecticides or miticides and are used to kill insects and mites.

Various approaches are used for the chemical control of insect pests which include:

Semiochemicals — Chemical Control of Behavior:

Chemosterilants — Chemical Control of Reproduction:

Insect Growth Regulators — Chemical Control of Development:

Conventional Insecticides: The Killer Chemicals:

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Insect management using mechanical control techniques

This is among the most traditional techniques, having been employed from the beginning of time. It entails actions such as gathering egg masses and various dormant phases, excavating contaminated sections or entire plants, pounding drums or tins, or digging trenches. When used as a coordinated effort by several farmers in a certain region, this strategy can show to be beneficial during the early stages of insect prevalence.

Mechanical management techniques eliminate or kill pests directly. They are widely liked by homeowners and gardeners since they are quick and efficient, and many of them work effectively for minor, urgent pest issues. Crucially, mechanical treatments are ideally suited for usage in conjunction with biological control in an integrated pest management strategy since they very rarely affect non-target species and the beneficial natural enemies of pests (see below). Large or vividly colored foliage feeders, including tomato hornworms, Mexican bean beetles, and Colorado potato beetles, can be harvested by hand. Many pests can be removed by shaking plants. For instance, plum curculio beetles can be removed from fruit trees by carefully hitting the tree limbs with a padded stick, and then gathering the adult weevils as they drop from the branches onto a white sheet. Aphids and mites on houseplants, gardens, and greenhouses may be removed with a powerful water spray. Mechanical control devices include mouse traps and fly swatters. Many soil insects are at risk of desiccation or avian predation due to cultivation or tillage.

Read: Insect management using physical control methods

Stomping on insects—literally or figuratively—is sometimes the most effective method among the traditional techniques to get rid of them! Simple physical or mechanical control techniques include hand-picking bagworms from juniper bushes, chopping tent caterpillars off shade trees, and using fly swatters and window screens to keep flying insects out of your house. The electronic bug killers are on the opposite extreme of the technological range. With the use of an electric grid, these advanced fly swatters draw flying insects to their premature demise by emitting an ultraviolet glow. The soothing sound of bugs sizzling on the grill allows owners to sleep better at night, even though bug zappers likely kill more beneficial insects than pests.

Trapping devices

Certain bug species can be effectively controlled with basic trapping devices. For example, greenhouses frequently utilize fly paper and sticky boards to keep leafhoppers and whiteflies under control. Wrapping a belt of folded hessian around the trunk with the open side facing down would protect fruit and shade trees against a variety of pests, such as plum curculio, gipsy moths, and codling moths. Insects become lodged in the folds of hessian as they ascend the trunk; these can be treated with pesticide or checked every day to remove the bugs. Sometimes crawling insects (such as chinchbugs or white-fringed beetles) are utilized as barriers to prevent them from migrating from one field to another. These barriers can be ditches or moats with high vertical walls. Pitfall traps are dug at 3-5 meter intervals in the ditch and filled with kerosene or creosote to kill the pests.

It was common practice for farmers to run a bale of chicken wire around their fields in the 1930s and 1940s to create dust with a team of horses or a tractor hitched behind it. The insects became dehydrated and eventually died as a result of the dust’s abrasive covering removing their cuticular waxes. It explains why crops grown close to a well-traveled dirt road frequently suffer less bug damage than crops on the other side of the same field, even though this is undoubtedly not the most effective form of pest management.

Temperature extremes

It is possible to destroy insects or stop them from hurting by using extremely high temperatures. Fertile crops have a longer shelf life when stored cold, and insect pest growth is inhibited. Certain varieties of vegetables can occasionally be treated with heat treatments instead of fumigation to eradicate insect larvae. To destroy the eggs and larvae of fruit flies (Tephritidae) before export, mangoes, for instance, are immersed in hot water baths (115°F for 68 minutes). Innovative Midwest farmers constructed tractor-driven flame throwers in the 1950s and 60s to burn off the stubble on corn fields. The idea was to eliminate a variety of pests that lived in the soil by creating a high enough temperature. The fuel utilized was liquid propane (LP gas).

In contrast to the majority of other pest management strategies, physical and mechanical methods frequently lose their usefulness or cost-effectiveness when implemented on a wide scale. For example, homeowners with five apple trees would find it reasonable to band trees with hessian to protect them against codling moths, while commercial farmers with 500 or 5000 trees would find it extremely labor-intensive.

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Insect management using physical control methods

Physical control refers to managing pests by techniques including through barriers (such as screens or row coverings), hand-pulling weeds, and capturing, or removing the pest. Physical controls also include electrocution (rat zappers) and thermal controls (heat and cold therapy).

These are techniques that physically prevent pest insects from getting to their hosts. Some examples of barriers include floating row coverings for many horticultural crops, plant collars to prevent cutworms from attacking plants like tomatoes, and window screens to keep plant pests and health-harming insects out of greenhouses and buildings. Cockroach traps in houses are one kind of trap that may be used for control. Apple trees can have cardboard bands put around them that capture codling moth larvae; the bands are then taken off and disposed of. It is possible to lure certain pests—like earwigs and slugs—to their demise using beer-filled submerged traps.

A typical physical barrier we employ to keep pests out of our houses is window screening. Furthermore, pests can be physically eradicated from plants. For instance, misting the plant with water can help remove certain aphids and mites from the leaf. During the winter, bagworm eggs that are hibernating inside the bags can be taken out of the plants and killed. Certain pests can be captured with traps, and plants can be shielded from disease-causing insects or pests with barriers. Applying a band of folded hessian around the tree trunk to create an artificial resting place for the caterpillars and subsequently destroying them is an efficient way to manage gypsy moth larvae on small trees.

Many insects utilize pheromones to find partners, alert other insects to danger, identify food routes, and draw other insects to a particular location. In IPM programs, these alluring materials have shown to be quite helpful as instruments for monitoring and sampling, as well as for preventing pests from reproducing or eliminating them under specific circumstances. Certain kinds of insects also find particular colors to be highly appealing. For instance, sticky surfaced traps and yellow have been used to monitor a range of insect infestations.

Physical control involves the use of hands-on or mechanical methods to actively target and eradicate the pest. Weed control usually involves the use of physical measures. Weeds can be eliminated and their reproduction stopped via tillage, fire, manual removal, grazing, and mowing. Tillage can also harm some insects by destroying their eggs or overwintering stages of development. One operation is insufficient to manage weeds.

Combining techniques like summer fallow, post-harvest tillage, post-seeding tillage, and seedbed preparation can effectively suppress perennial weeds and their seedlings. The options will change depending on the crop, geography, level of infestation, soil quality, and equipment availability.
The choice of machinery is influenced by soil variables. For instance, mowing may be impeded by stones, and recurrent tillage may be avoided by moisture conservation. Take everything into account before creating an integrated control program.

Read: Options for Controlling Insect Pest Populations in Field Conditions

Harvest Practices

Strip harvesting keeps a strip of unharvested crops in the field, protecting it from mass insect migration, preserving natural opponents of pests, and enhancing snow management. Insects like beet webworms, pea aphids, cutworms, and grasshoppers may be forced to relocate if a whole field of afflicted crops is harvested. The harvest frequently removes beneficial insects, their home, and their food source if the crop contains them, which it most likely would if it is contaminated. With the harvest of the crop, the following generation of parasites may potentially be eliminated from the land. As a result, the insect frequently switches to a crop that is unaffected by its natural enemies. Strip harvesting contributes to the upkeep of a balanced ecology.

Sometimes a crop can be saved by swathing it early. Sawfly-infested wheat may have collapsed by the time it reaches maturity, making harvesting unfeasible. Sickly fields can be protected against weeds and pests like wheat stem sawflies by harvesting them early or turning them into silage or hay.
Grain mixtures should ideally be straight unless there is a suspicion of disease or insect presence, or unless rapid drying is necessary. Straight mixing enhances snow management and allows for longer stubble. Harvest timing may have an impact on production and the development of diseases. In late spring, pods are attacked by Alternaria black spot, which affects mustard and canola. Shattering losses from infected crops might be minimized by swathing them early. To promote drying, lay swaths so that air can flow beneath the grain. Sclerotritinia white mold can grow over the swath if the canola is wet.

Cereal crop grains that have overwintered in the swath, especially when covered in snow, may get contaminated with fungus that, under some situations, can create mycotoxins. Poisonous substances called mycotoxins are produced naturally as byproducts of fungi like Aspergillus, Fusarium, and Cephaolosporium. Vomitoxin, which Fusarium may make, causes sickness in people and loss of productivity in animals. It can be found in grain and hay. Ochratoxins are a class of mycotoxins that may cause cancer. They are present in tiny levels in grains that heat up while being stored on prairie farms. The flesh of pigs and poultry that have eaten tainted feed occasionally contains these mycotoxins.

Mowing and Hand-pulling

Regular mowing reduces the root stores of perennial weeds. Additionally, it will stop weeds that are annual or biennial from producing seeds. When plants are in buds, perennial weeds have the lowest root stores. This is the time if there will just be one mowing scheduled. Field bindweed and other prostrate weeds are not successfully removed by mowing. Agricultural insect pests’ helpful enemies are frequently harmed by mowing. To modify their mowing techniques, farmers must be aware of the life cycle and habitat requirements of the beneficial species. The provision of habitat for birds is a clear example. Many birds nest in the grass, and they eat enormous amounts of insects. One reason for the death of nestlings is early mowing.

Hand pulling works best for annual and biennial weeds, while tiny areas of persistent weeds can be pulled up frequently. Eliminating annual weeds stops seeds from being produced. If weeds are in blossom, stop the distribution of seeds by bagging and burning them. When attempting to stop the emergence of new species, hand pulling is most practical. On pedigreed seed farms, hand rouging is a standard procedure and may be used in broad regions as long as the infestation is not severe.

Summer fallow

Summer fallow is a practice that helps prevent soil erosion, manage weeds, and preserve moisture, nutrients, and crop residue. Perennial weeds are best controlled by summer fallow. Tillage encourages weed seeds to germinate, which means that it also helps reduce the amount of weed seeds in the soil. Weed flushes are managed using pesticides or tillage as they emerge. In situations where tillage is ineffective or when soil erosion is a concern, use herbicides. Use caution while using summer fallow since it increases salinity, erosion, and the loss of organic matter. Wide-sweeping field cultivators cut the roots of both annual and perennial weeds. A rod weeder will pierce the soil once it has been disturbed, effectively controlling annual weeds while minimizing moisture loss. Blade cultivators are useful in arid regions where less disturbance of the soil is preferred. till the calm, hot, and dry weather arrives. Summer fallow for one year will lessen but not completely eradicate weed issues. Weed seeds that have gone dormant will still sprout and appear in the following years.

Tillage

Tillage easily gets rid of annual weeds as well as biennial weeds with short tap roots and perpetual seedlings. It is essential to holistic weed management. It is simpler to manage younger weeds. The degree of soil disturbance has a direct bearing on tillage efficacy. Tillage has a larger impact on weed control. The residue cover, soil type, soil moisture, growing conditions, and weed development all influence the tool selection. While blade tools, like the Noble or Victory blade cultivators, can reduce waste, they are not very useful in chilly, damp weather. Plant residue-burying implements work well in damp environments but raise the risk of erosion. In the Brown and Dark Brown soil zones, less tillage is preferable, especially after dry years that leave minimal residue cover and on sandier soil. Rod weeders and field cultivators are an excellent middle ground.

Pre-seeding tillage:

The majority of weed seeds germinate more readily when shallow tillage (less than 7.5 cm) is applied in the early spring. The seedlings will be destroyed and a seedbed will be prepared by a second shallow tillage. If there is a lot of crop residue, use an instrument with a disc shape. When there is less residue, a cultivator or rod weeder will operate. This method works well on weeds like hemp nettle, wild oats, and mustards that sprout in chilly soil.

Post-seeding tillage:

This method will manage weeds that come up with or soon after potatoes, sunflowers, and cereal crops. Post-seeding tillage should be done cautiously since it can occasionally result in serious crop damage. For example, post-seeding tillage using interrow cultivation for maize and vegetable production is less harmful than blanket tillage. Nonetheless, it is generally safe to rod weed cereal crops to remove early emergent weeds while the crop sprouts are still below the rod weeder’s depth. Crop damage will differ depending on the kind of soil, the crop, the depth of planting, and the weather at the time of tillage. The best soil for tillage is hard, somewhat deep soil that has had deeper sowing. If post-seeding tillage is used, some crop loss is unavoidable and the grower should accept this fact.

Post-emergence tillage:

One can harrow wheat and barley after emergence if they are sown 8 to 10 cm deep and up to 25% heavier than usual. Before tillers develop, till between the first and fourth leaf stage. Parallel to the seed rows, light harrows can be drawn gently. Delaying crop maturity by at least two or three days can be achieved by post-emergent tillage with a harrow. If crop stress is present, do not tillage. More harm will result from this in a dry spring than the weeds themselves could ever do. In comparison to wheat, barley is more vulnerable to harm. Because straw clogs harrow and severely damage crops, post-emergent harrowing is not advised in areas with a high rubbish cover. Most of the time, herbicides are a superior substitute.

Inter-row tillage:

In row crops like potatoes and sugar beets, tillage can help control the weed population. Early and light tillage is recommended for the first time. If necessary, further passes may be made. Be cautious to prevent harm to your crops.

Fall tillage:

Early autumn tillage can be used to suppress winter annual seedlings as well as some perennial weeds. To keep your stubble in place in the Brown soil zones, use a blade cultivator. The remaining soil zones can be worked using field cultivators. If there is little stubble, wait till early the next spring and avoid autumn tillage. The kind of weed determines when to do autumn tillage. Autumn tillage is often carried out between crop harvest and soil freeze-up. For winter annuals, fall tillage and fall herbicide applications work quite well and need to be included in most weed management plans.

Grazing

Grazing does the same thing as mowing in terms of weed management. Preventing the formation of seeds is the primary goal of weed management. Grazing needs to stop the formation of seeds to be effective. As a result, while designing a grazing program, the age of the target weed is crucial. When weeds are young, they are most edible, and as they become older, they become less edible. Grazing needs to begin before seeds develop and while weeds are still edible. Few things can be accomplished by grazing as much as by mowing. This will vary depending on the grazing animal, the grazing method, and the target weed. Because grazing animals are often unavailable when needed, and because fencing and management are frequently insufficient or inappropriate to guarantee that top growth and seed production are restricted, many grazing plans fail to effectively control weeds.

The grazing system ought to minimize the grazing animal’s options. Successful systems have been implemented that use herded sheep and goats and short-duration cattle grazing. For a brief period, a high density of animals per unit space is referred to as short duration. The capacity of weeds to be palatable to grazing animals determines selectivity. Growing older plants lose some of their palatability. As a result, when weeds are at their most appetizing early in the season, you should begin to graze.

The type of weed, its age, the availability of animals for grazing, and the animal’s nutritional needs should all be taken into account when selecting a grazing animal. Every animal species typically has a distinctive, favored diet. Sheep like broader-leaved plants, including a lot of weeds, since they are intermediate feeders. Sheep steer clear of thick grass, debris, and plants. Unlike other domestic animals, sheep may change their diet to include more grass or browse. Sheep are probably the finest animals to test on many problematic weeds because they are utilized to collect weedy plants more frequently than other species.

Trap Strips

Crops that are particularly appealing to insects might be planted in strips around fields. Insecticides or cultural methods might be used to target and eliminate the pest insects in this area. These visually appealing crops might just be the same crop planted at a different period, or they could even be weeds or volunteer crops. Adult maize borer, for instance, lays its eggs in the highest plants. Corn borers are concentrated in trap strips that are sown earlier, to a quicker maturing variety, or adjacent to a grassy strip, tramline, or headland. These strips also effectively regulate the remaining portion of the field.

Moreover, trap strips work well against wheat stem sawflies. To lay their eggs, sawflies will only fly as far as is required. When sawflies are sown around a field, they will deposit their eggs in trap strips made of a solid-stemmed, resistant type. In the solid stem, larvae cannot live. To make the stems more developed and hence more appealing to females who lay eggs, sow sawfly trap strips earlier than the main crop. Trap strips reduce erosion, increase soil moisture, and overwinter the survival of fall crops and perennial crops.

Fire

It is not advisable to use fire for pest control. Since the temperature at ground level is rarely high enough to damage pests in the soil, it is frequently unsuccessful. Crop waste and organic debris that may be absorbed into the soil are destroyed by fire. If agricultural residue is destroyed by fire, the soil may become more prone to erosion. For helpful insects, fire may be very harmful. While beneficial insects hibernating close to the soil’s surface may be killed by fire, healthy pest larvae and pupae may not be destroyed.

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Options for Controlling Insect Pest Populations in Field Conditions

The term “pest control” describes the management or regulation of a species that is classified as such, generally because it is seen to pose a risk to public health, the environment, or the economy.
Agriculture and pest management go back as least as far as they both began since crops have always needed to be kept free of pests. Protecting crops from herbivores that compete with people and from other plant species is beneficial for maximizing food output.
The traditional method was most likely the first to be used since it is very simple to kill larger competitive herbivores like crows and other birds that eat seeds, as well as to eradicate weeds by burning them or burying them. Crop rotation, companion planting (also referred to as intercropping or mixed cropping), and the deliberate cultivation of cultivars resistant to pests are examples of long-standing techniques.

The only reason many pests are becoming an issue is because of direct human activity. Changing these behaviors can frequently significantly lessen the insect issue. Bins with locking lids were installed by several homeowners, discouraging raccoons from coming around. House flies are almost a worldwide phenomenon that prefer to congregate whenever there is human activity, particularly in areas where food or food waste is exposed. In a similar vein, several beach resorts now consider seagulls to be pests. Visitors would frequently give the birds leftover fish and chips, and eventually, the birds would grow hostile towards people as a result of being dependent on this food source. For example, the urban Red Fox uses its territorial behavior against the animal, generally in combination with chemical repellents that do not harm it.

Removal of breeding grounds:

Managing garbage properly and draining stagnant water removes many insects’ nesting grounds. Many undesirable species find food and shelter in garbage, and it also creates a place where standing water may gather and serve as a mosquito breeding ground. Rats, cockroaches, mosquitoes, flies, and other pests are significantly less of an issue in communities with appropriate waste collection and disposal than they are in those without.
Additionally, open-air sewers provide plenty of space for bugs to breed. This issue is resolved by installing and maintaining a suitable sewage system.

Read: Insects: Classification and some common diseases caused by insects

Food-Based Poisoned Baits:

Insect control with food-based baits is a successful and focused approach. An insecticide (such as organophosphates, carbamates, or pyrethroids) and a toxicant (typically oil, sugar, or water) are the conventional components of bait. The base material, known as the carrier, is often grain or animal protein. An alternative to chemical poisoning in baits is biological poisoning. Biohazards include worms parasitic on humans, fungi, and Bacillus thuringiensis (Bt). In many cases, baits serve as arrestants rather than being very appealing to insects. The base substance does not attract the bug, but it tastes good, so the insect will eat it if it comes across it. Therefore, to ensure wide distribution, baits are applied via either ground or aerial broadcasting. Toxic baits are frequently low-cost, eco-friendly insect control solutions. Although poisoned bait is frequently used to manage insect populations, its effectiveness diminishes in situations when there are alternative available food sources, such as trash. Since ancient times, people have used poisoned foods to drive away wolves, birds that were thought to pose a crop threat, and other animals.

Field burning:

A more conventional technique to manage insect populations is field burning. All dangerous species, including any leftover eggs, are eliminated by burning the whole field after harvest. Your land will be thoroughly cleaned with this kind of pest control. A custom followed by many farmers involves burning all of the sugar cane fields following harvest to eradicate any insects or their eggs.

Hunting:

To construct an IPM program, a region must be monitored for insects and diseases. In addition to helping us save money, identifying target pests at the correct time and using the proper solution will also assist preserve the natural adversary in the region where we wish to place traps. The IPM tenets serve as the foundation for these traps. With the help of these traps, we can monitor the insects and use other methods of control, such as biological and cultural ones, without using chemicals. Traps play a significant role in IPM programs. They may be applied to lessen the impacts of pollutants in fields, which is also a program that is good for people. These kinds of traps have to be utilized in nations where the use of pesticides is widespread. Farmers should be informed about the trapping system by the Extension Department to promote prosperity and a chemical-free environment.

Airguns allow a safe and effective form of pest control, they allow a selective form similar to the above hunting but with a much “safer” effective range. Traps have been used for killing off mice found in houses, for killing wolves, and for capturing raccoons and stray cats and dogs for disposal by town officials.

Poison spray:

One popular form of pest management is the use of poisons sprayed from trucks, palm-carried devices, or airplanes. Every town in the United States of America frequently uses a town-owned vehicle to spray for mosquitoes on each street once or twice a week. To eradicate pests that may endanger the crops, crop dusters frequently fly over agricultural areas and spray poison. Many people think that poisoning the area surrounding their houses, businesses, or yards is significantly more appealing than letting insects proliferate there.

Space fumigation:

A project where a structure is covered or made airtight and then a lethal gas is introduced for a lengthy duration (24–72 hours) at a concentration that kills. Space fumigation tackles all phases of a pest’s life cycle, despite its high cost.

Space treatment:

A long-term endeavor for insect and mite control in field crops is using misting or fogging applicators. In the atmosphere of a building, liquid pesticide is released. Most internal work may continue in a building that has been treated, albeit at the expense of the penetrating effects, as there is no need for a structure to be evacuated or sealed 100%. Insecticides that minimize long-term residual effects are often used as contact agents.

Sterilization:

The early 1970s saw the attempt at conducting laboratory experiments using U-5897 (3-chloro-1,2-propanediol), but these efforts were unsuccessful. Stay tuned for further research on sterilization bait. Steaming soil is an additional efficient way to sterilize soil. Hot steam is introduced into the soil to eliminate pests.

Elimination of infected plants:

In order to stop an insect species from spreading, forest services may occasionally remove every tree in a region where some trees are afflicted. Certain insect-infested farms have been completely burnt to stop the issue from spreading.

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Insects: Classification and some common diseases caused by insects

Insects make up the most diverse group in the animal kingdom. According to scientists, an estimated one million bug species inhabit every imaginable habitat on Earth, including glaciers and volcanoes.
We benefit from insects because they pollinate our food crops, break down organic materials, provide scientists hints about possible cancer treatments, and even assist in solving crimes. They may also injure humans by propagating illnesses and causing harm to buildings and plants.

Classification of insects

All insects on the earth belong to the arthropods.

Every member of the phylum Arthropoda has three pairs of legs, a segmented body, and an exoskeleton. The phylum Arthropoda also includes the following classes: Myriopoda (millipedes and centipedes), Crustacea (crabs), and Arachnida (spiders).
The insects that live on Earth are members of the class Insecta. The most common division is divided into 29 orders. These twenty-nine orders classify related insect families based on the physical traits of the insects. Using evolutionary relationships rather than physical characteristics, some insect taxonomists classify insects differently. Since you can see the physical similarities, it makes more sense to utilize the system of twenty-nine orders to identify an insect.

The body is divided into 3 sections:

  • head,
  • thorax,
  • abdomen.

They have 6 legs attached to the thorax. Usually, they have wings that are joined to the thorax. The elytrae, or hard wings, of insects like beetles, protect the flying wings and lay flat on the abdomen.

Read: Enzyme Activity – Questions and Answers Part 3

Common diseases caused by insects

Insects are frequent carriers of several diseases. An organism that transfers illness from one host to another is called a vector. There are two primary ways that insects transmit bacterial, viral, and protozoan diseases. Either by their feces, as in the cases of Chagas’ Disease carried by Triatoma bugs or epidemic typhus spread by human body lice, or by their bite, as in the instance of malaria spread by mosquitoes.

The spread of illnesses is attributed to several insects. Some of the most well-known insect vectors are mosquitoes, which spread a variety of deadly tropical illnesses. among them are yellow fever, dengue fever, and malaria. Flies are just another big category of vectors. Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense are protozoan trypanosomes that cause African trypanosomiasis, often known as sleeping sickness. Sandfly species function as vectors for protozoan Leishmania species, which cause leishmaniasis. Within the larger category of insect vectors are ticks and lice. Members of the bacterial genus Rickettsia are spread by lice, while the bacteria that causes Lyme disease, Borrelia burgdorferi, is spread by ticks. The bacteria that causes epidemic typhus, for instance, is spread by the human body louse. It is called Rickettsia prowazekii.

Insect Borne Diseases
DiseaseVectorEast, West, and Central Southern Africa.
MalariaMosquitoesGlobal tropical and subtropical areas.
Yellow FeverMosquitoesTropical areas of Africa and Central and South America
Dengue FeverMosquitoesTropical Africa, South East Asia, South America and the Pacific.
Japanese B
Encephalitis
Mosquitoes, TicksThe Far East and South East Asia. Forested areas of Central & Eastern Europe, Scandinavia, and the former USSR.
FilariasisMosquitoes, BlackfliesGlobal tropical and subtropical areas.
Lyme DiseaseTicksEurope (inc. UK), USA, Australia, China & Japan.
LeishmaniasisSandfliesGlobal tropical and subtropical areas including the Mediterranean.
Sleeping SicknessTsetse FliesWorldwide
Chagas DiseaseAssassin BugsTropical South and Central America.
Typhus FeverTicks & LiceWorldwide

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Enzyme Activity – Questions and Answers Part 3

1. What is the relationship between vitamins and enzyme cofactors? Enzyme Activity.

Many vitamins are enzyme cofactors that the organism cannot synthesize and must be obtained from the diet.

2. For the enzymatic reaction what is the effect of a substance with the same spatial conformation as an enzymatic substrate? How is this type of substance known?

Substances that “simulate” substrates can bind to the activation center of enzymes thus blocking the true substrates from binding to these enzymes and paralyzing the enzymatic reaction. Such “fake substrates” are called enzyme inhibitors.

The binding of enzyme inhibitors to enzymes can be reversible or irreversible.

Many medical drugs, for example, some antibiotics, antivirals, antineoplastics, antihypertensive, and even sildenafil (trade name Viagra), are enzyme inhibitors that block enzyme activity.

3. What is the action mechanism of the antibiotic penicillin?

Penicillin, discovered by the Scottish doctor Alexander Fleming in 1928, is a drug that inhibits enzymes necessary for synthesizing peptidoglycans, a constituent of the bacterial cell wall. With the inhibition, the bacterial population stops growing because there is no new cell wall formation.

Fleming won the Nobel Prize in Medicine for the discovery of penicillin.

4. What is the action mechanism of the antiretroviral drugs called protease inhibitors which are used against HIV infection?

Protease inhibitors are some of the antiretroviral drugs used to treat HIV infection. Protease is an enzyme necessary for the assembly of HIV after the synthesis of its proteins within the host cell. The protease inhibitor binds to the activation center of the enzyme blocking the formation of the enzyme-substrate complex and the enzyme activity thus impairing the viral replication.

5. What are allosteric enzymes?

Allosteric enzymes have more than one activation center and to which other substances, called allosteric regulators, bind.

Allosteric regulators can be allosteric inhibitors or allosteric activators. The interaction between an allosteric enzyme and the allosteric inhibitor disallows the binding of the substrate to the enzyme. The interaction between the allosteric enzyme and the allosteric activator allows the binding of the substrate to the enzyme and sometimes increases the affinity of the enzyme for the substrate. This regulatory phenomenon of enzyme activity is called allosterism.

Read: Enzyme Activity – Questions and Answers Part 2


6. What are zymogens?

Zymogens, or proenzymes, are enzymes secreted in inactive form. Under certain conditions a zymogen shifts to the active form of the enzyme. Zymogen secretions in general happen because the enzyme activity can harm the secretory tissue. For example, the pepsinogen secreted by the stomach becomes active under acid pH turning into the enzyme pepsin. Other well-known zymogens are trypsinogen and chymotrypsinogen, enzymes that are secreted by the exocrine pancreas and which become trypsin and chymotrypsin respectively.

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